Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-10-11
pubmed:abstractText
Non-neoplastic mammary gland, 20 benign tumors and 206 carcinomas of the breast were immunohistochemically examined for expression of HLA-A, -B, -C, HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). In contrast to cells from benign lesions, tumor cells of 51.2% of carcinomas had an abnormally low content of HLA-A, -B, and -C determinants ranging from reduction of antigenic density per cell (28.8%) over an incomplete (15.6%) to complete loss of antigens (6.8%). Associated with lymphohistiocytic stromal infiltrates, HLA-D/Ii determinants were found to be induced in benign duct and acinar epithelium after the order Ii greater than or equal to HLA-DR greater than or equal to HLA-DP greater than or equal to HLA-DQ. These antigens were also expressed, mostly noncoordinately, in 55.5% of carcinomas, and in 98 cases according to the above order. In 28.6%, Ii expression clearly exceeded HLA-D antigen expression; conversely, 6.2% contained HLA-DR+/Ii- tumor cell subsets. In breast carcinoma, the association of reduced HLA-A, -B, and -C expression and a noninduction of HLA-DR was highly significant (P less than 0.0009), suggesting an abnormal signal acting down-regulating on the expression of both classes of antigens. Because the modality of HLA-A, -B, and -C and HLA-D/Ii expression correlated with neither tumor type nor grade, it might be an independent parameter.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-13499785, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2408443, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2435790, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2443365, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2459333, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2462591, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2823150, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2829169, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2831293, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2902140, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2956199, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-2989190, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3029232, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3125670, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3140668, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3192729, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3263576, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3264384, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3312546, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3316049, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3402430, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3425689, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3435699, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3455781, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3493432, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3520195, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3552208, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3874223, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3918945, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-3951539, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-4133807, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6087025, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6187075, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6193308, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6198089, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6199417, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6336658, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6365133, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6370519, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6431411, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6576808, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6581642, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6591601, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-667938, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6746029, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6955026, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-6973570, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-7002399, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-7009164, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-7016338, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-7021603, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-7022944, http://linkedlifedata.com/resource/pubmed/commentcorrection/2549795-83651
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-83
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...