| pubmed-article:2548640 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C0032145 | lld:lifeskim |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C0013682 | lld:lifeskim |
| pubmed-article:2548640 | lifeskim:mentions | umls-concept:C0007382 | lld:lifeskim |
| pubmed-article:2548640 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2548640 | pubmed:dateCreated | 1989-9-25 | lld:pubmed |
| pubmed-article:2548640 | pubmed:abstractText | We compared urokinase-type plasminogen activator (u-PA) in fluid phase and u-PA bound with its receptor on human blood monocytes with respect to proteolytic activity and susceptibility to inactivation by the plasminogen activator inhibitors PAI-1 and PAI-2. Receptor-bound u-PA is catalytically twice as efficient as fluid-phase u-PA. Fluid-phase u-PA is susceptible to rapid inhibition by PAI-1 and PAI-2 at an estimated PAI:u-PA molar ratio of 2:1. In contrast, u-PA bound to endogenously occupied receptors is inhibited by PAI-2 only at PAI:u-PA molar ratios of 20:1, but is not inhibited by PAI-1, u-PA/PAI-1 and u-PA/PAI-2 complexes bind to the receptor with a tenfold lower affinity than u-PA itself. Thus, competition of u-PA/PAI complexes with fluid-phase u-PA for binding to the receptor is unlikely to affect the overall plasminogen activator activity of the monocyte. These findings demonstrate that the activity of receptor-bound u-PA can be modulated by PAI-2, but not by PAI-1, to adjust the cell's proteolytic activity to different local situations. | lld:pubmed |
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| pubmed-article:2548640 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2548640 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2548640 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2548640 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2548640 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2548640 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:2548640 | pubmed:author | pubmed-author:RemoldH GHG | lld:pubmed |
| pubmed-article:2548640 | pubmed:author | pubmed-author:KirchheimerJ... | lld:pubmed |
| pubmed-article:2548640 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2548640 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:2548640 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2548640 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2548640 | pubmed:pagination | 1396-402 | lld:pubmed |
| pubmed-article:2548640 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2548640 | pubmed:meshHeading | pubmed-meshheading:2548640-... | lld:pubmed |
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| pubmed-article:2548640 | pubmed:meshHeading | pubmed-meshheading:2548640-... | lld:pubmed |
| pubmed-article:2548640 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2548640 | pubmed:articleTitle | Functional characteristics of receptor-bound urokinase on human monocytes: catalytic efficiency and susceptibility to inactivation by plasminogen activator inhibitors. | lld:pubmed |
| pubmed-article:2548640 | pubmed:affiliation | Department of Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA 02115. | lld:pubmed |
| pubmed-article:2548640 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2548640 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2548640 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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