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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1989-9-21
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pubmed:abstractText |
The actions of endothelin, an endogenous vasoconstrictor compound with potent effects on various parameters of Ca2+ metabolism in peripheral tissue, were studied in several neuronal preparations. Endothelin, by itself, did not alter resting intracellular free Ca2+ levels or Ca2+ influx in either rat or chicken brain preparations; nor did it affect depolarization (K+) induced changes in these parameters. Endothelin also had no effect on the binding of [3H]-nitrendipine or [125I]-omega-conotoxin to "L " or "N" type channels respectively nor did it induce the release of endogenous acetylcholine from brain slices. The results show that, despite the proposed role of endothelin on voltage sensitive Ca2+ channels in peripheral tissue and despite the existence of endothelin binding sites on both smooth muscle and neurons, endothelin has no measurable effects on Ca2+ metabolism in neural tissue of central origin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
|
pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1332-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2548495-Acetylcholine,
pubmed-meshheading:2548495-Animals,
pubmed-meshheading:2548495-Biological Transport,
pubmed-meshheading:2548495-Brain,
pubmed-meshheading:2548495-Calcium,
pubmed-meshheading:2548495-Calcium Channels,
pubmed-meshheading:2548495-Cytoplasm,
pubmed-meshheading:2548495-Endothelins,
pubmed-meshheading:2548495-Neurons,
pubmed-meshheading:2548495-Peptides,
pubmed-meshheading:2548495-Rats,
pubmed-meshheading:2548495-Synaptosomes
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pubmed:year |
1989
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pubmed:articleTitle |
Effect of endothelin on Ca2+ influx, intracellular free Ca2+ levels and ligand binding to N and L type Ca2+ channels in rat brain.
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pubmed:affiliation |
Biomedical Defence Section Defence Research Establishment Suffield Ralston, Alberta, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro
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