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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-8-14
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pubmed:abstractText |
The effects of synthetic analogs of sarafotoxin (STX) S6b, a snake venom peptide with a high sequence homology to the endothelium-derived vasoconstrictor endothelin (ET), on ET receptor binding activity and cytosolic free Ca2+ concentration [( Ca2+]i) were studied in cultured rat vascular smooth muscle cells. Binding studies revealed that [Cys1-15, Cys3-11] STX competed with 125I-ET for the binding to its vascular receptors with lower affinity than that of ET, but was far more effective than [Cys1-11, Cys3-15]STX in inhibiting the binding. [Cys1-15, Cys3-11]STX had a less potent effect on increasing [Ca2+]i than ET, whereas [Cys1-11, Cys3-15]STX was inactive. These data suggest that there may exist heterogenous subpopulations of the vascular ET/STX receptors, and that the proper double cyclic structure of STX is essential for interacting with its putative receptors to induce the [Ca2+]i response.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Disulfides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Endothelin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Viper Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/sarafotoxins s6
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
441-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2546552-Animals,
pubmed-meshheading:2546552-Binding, Competitive,
pubmed-meshheading:2546552-Cells, Cultured,
pubmed-meshheading:2546552-Disulfides,
pubmed-meshheading:2546552-Endothelium, Vascular,
pubmed-meshheading:2546552-Kinetics,
pubmed-meshheading:2546552-Muscle, Smooth, Vascular,
pubmed-meshheading:2546552-Rats,
pubmed-meshheading:2546552-Receptors, Cell Surface,
pubmed-meshheading:2546552-Receptors, Endothelin,
pubmed-meshheading:2546552-Vasoconstrictor Agents,
pubmed-meshheading:2546552-Viper Venoms
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pubmed:year |
1989
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pubmed:articleTitle |
Interaction of synthetic sarafotoxin with rat vascular endothelin receptors.
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pubmed:affiliation |
Department of Medicine, Tokyo Medical and Dental University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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