Linked Life Data

2546439

Source:http://linkedlifedata.com/resource/pubmed/id/2546439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 1
pubmed:dateCreated
1989-8-11
pubmed:abstractText
Previous studies have indicated that motor center ("feedforward") activity is important for hormonal and metabolic responses to exercise. Now, epidural blockade at vertebrae L3-L4 was used to evaluate the importance of afferent neural feedback from working muscles. Six healthy, young males cycled for 20 min at 55 +/- 4% (mean +/- SE) of maximal oxygen uptake with, as well as without, epidural anesthesia. During anesthesia cutaneous sensory blockade was present below segment T11-12, the postexercise ischemic pressor response was attenuated from 34 +/- 9 to 14 +/- 4 mmHg, muscle strength reduced to 80 +/- 5% of control, and perceived exertion (Borg scale) was increased. At rest hormonal and metabolic parameters did not change in response to epidural anesthesia. During exercise, responses of catecholamines, insulin, glucagon, and growth hormone (GH) in plasma as well as glucose production and utilization, plasma free fatty acids, and plasma glycerol were similar in epidural and control experiments (P greater than 0.05). In contrast during submaximal exercise, plasma concentrations of adrenocorticotropin (ACTH) and beta-endorphin increased only in experiments without epidural anesthesia. The data indicate that impulses in afferent nerves from the working muscles are essential for the ACTH and beta-endorphin responses to submaximal dynamic exercise in humans. Afferent nervous activity is probably less important than efferent activity from motor centers for responses of GH, catecholamines and insulin, and, in turn, extramuscular fuel mobilization in exercise.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E95-101
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:2546439-Adrenocorticotropic Hormone, pubmed-meshheading:2546439-Adult, pubmed-meshheading:2546439-Afferent Pathways, pubmed-meshheading:2546439-Anesthesia, Epidural, pubmed-meshheading:2546439-Arteries, pubmed-meshheading:2546439-Blood Glucose, pubmed-meshheading:2546439-Blood Pressure, pubmed-meshheading:2546439-Epinephrine, pubmed-meshheading:2546439-Exercise, pubmed-meshheading:2546439-Fatty Acids, Nonesterified, pubmed-meshheading:2546439-Feedback, pubmed-meshheading:2546439-Glycerol, pubmed-meshheading:2546439-Growth Hormone, pubmed-meshheading:2546439-Heart Rate, pubmed-meshheading:2546439-Humans, pubmed-meshheading:2546439-Insulin, pubmed-meshheading:2546439-Lactates, pubmed-meshheading:2546439-Lactic Acid, pubmed-meshheading:2546439-Male, pubmed-meshheading:2546439-Muscles, pubmed-meshheading:2546439-Norepinephrine, pubmed-meshheading:2546439-Oxygen Consumption, pubmed-meshheading:2546439-beta-Endorphin
pubmed:year
1989
pubmed:articleTitle
Hormonal and metabolic responses to exercise in humans: effect of sensory nervous blockade.
pubmed:affiliation
Department of Medical Physiology B, Panum Institute, University of Copenhagen, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't