Linked Life Data

2546406

Source:http://linkedlifedata.com/resource/pubmed/id/2546406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1989-8-21
pubmed:abstractText
In pieces of the rabbit retina, histamine (HI) had no significant effect on cAMP accumulation; however, HI inhibited forskolin-evoked accumulation of the nucleotide. Mepyramine (H1-antagonist) was without effect, while cimetidine (H2-antagonist) antagonized the HI action. Dimaprit (H2-agonist) mimicked the HI action, however its action was not significantly affected by H2-antagonists. Since phosphodiesterase (PDE) inhibitors prevented the HI action it is suggested that HI-induced inhibition of the forskolin effect results from HI-induced activation of cAMP breakdown. The muscarinic agonist carbachol, and to a lesser extent HI, both increased [3H]inositol incorporation and intensified accumulation of [3H]inositol phosphates in the rabbit retina.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0065-4299
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Histamine-mediated regulation of cAMP levels and inositol phosphate metabolism in isolated rabbit retina.
pubmed:affiliation
Department of Biogenic Amines, Polish Academy of Sciences, Lodz-1, Poland.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't