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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1989-8-18
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pubmed:abstractText |
The trans activator (p40tax) of human T-cell leukemia virus type I (HTLV-I) is a transcriptional factor that activates the long terminal repeat (LTR) of HTLV-I and interleukin-2 receptor alpha. We examined the HTLV-I enhancer responsible for tax-mediated trans activation and identified (A/T)(G/C)(G/C)CNNTGACG(T/A) as a plausible tax-responsive element (TRE). The putative TRE in the LTR was found to be different from the elements required for activation by cycle AMP and 12-O-tetradecanoylphorbol-13-acetate, although these elements overlapped each other. The TRE was also different from a binding site of an NF-kappa B-like factor that was identified in the interleukin-2 receptor alpha promoter and human immunodeficiency virus LTR as a TRE. The latter result was further demonstrated by the failure of the NF-kappa B sequence to compete with the TRE of the LTR in a protein-binding assay. These findings indicate that tax function and its cascade can modulate activities of various enhancer sequences, which are probably regulated by distinct DNA-binding factors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2822255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2826822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2830620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2831395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2835230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2838755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2838905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2840644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2844710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2849741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2875459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2986109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2990028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2990037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2992082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-2996140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3001699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3011413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3011423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3018737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3022280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3024966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3025604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3030566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3035544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3036825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3037548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3091258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3132714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3174625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-3475568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-6091270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-6193397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-6261256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2545901-6979048
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3234-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2545901-Base Sequence,
pubmed-meshheading:2545901-Cell Line,
pubmed-meshheading:2545901-Cyclic AMP,
pubmed-meshheading:2545901-Enhancer Elements, Genetic,
pubmed-meshheading:2545901-Gene Expression Regulation,
pubmed-meshheading:2545901-HTLV-I Antigens,
pubmed-meshheading:2545901-Human T-lymphotropic virus 1,
pubmed-meshheading:2545901-Humans,
pubmed-meshheading:2545901-Molecular Sequence Data,
pubmed-meshheading:2545901-Mutation,
pubmed-meshheading:2545901-Plasmids,
pubmed-meshheading:2545901-Protein Binding,
pubmed-meshheading:2545901-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:2545901-Tetradecanoylphorbol Acetate,
pubmed-meshheading:2545901-Trans-Activators,
pubmed-meshheading:2545901-Transcription Factors,
pubmed-meshheading:2545901-Transfection
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pubmed:year |
1989
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pubmed:articleTitle |
A unique enhancer element for the trans activator (p40tax) of human T-cell leukemia virus type I that is distinct from cyclic AMP- and 12-O-tetradecanoylphorbol-13-acetate-responsive elements.
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pubmed:affiliation |
Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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