Linked Life Data

2545656

Source:http://linkedlifedata.com/resource/pubmed/id/2545656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-8-25
pubmed:abstractText
The minimal inhibitory concentrations (MICs) of nine antibiotics were determined by agar dilution on 123 strains of Streptococcus pneumoniae (65 penicillin sensitive, 42 intermediate resistant and 16 resistant). The antimicrobial agents tested were penicillin G, clindamycin, trospectomycin, daptomycin, teicoplanin, cefpodoxime, ciprofloxacin, ofloxacin and vancomycin. Of these, daptomycin, teicoplanin and vancomycin demonstrated the greatest in-vitro activity against penicillin-resistant strains (MIC90s less than or equal to 0.25 mg/l). Ciprofloxacin, ofloxacin and trospectomycin had equivalent activities unaffected by penicillin-susceptibility (MIC90 of both quinolones 2.0 mg/l, and of trospectomycin 4.0 mg/l). Cefpodoxime was also active in vitro against all strains (MIC90 2.0 mg/l), but MICs increased with increasing penicillin-MICs. Most penicillin-susceptible strains were susceptible to clindamycin, but many penicillin intermediate resistant and resistant strains were resistant to this drug. Results of this study indicate that several newly introduced and experimental antibiotics have potential in the treatment of infections caused by resistant strains of Str. pneumoniae.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
509-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Susceptibility of penicillin-sensitive and -resistant strains of Streptococcus pneumoniae to new antimicrobial agents, including daptomycin, teicoplanin, cefpodoxime and quinolones.
pubmed:affiliation
Department of Pathology (Clinical Microbiology), Hershey Medical Center, PA 17033.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't