Linked Life Data

2544468

Source:http://linkedlifedata.com/resource/pubmed/id/2544468

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-8-3
pubmed:abstractText
Vitamin D3 deficiency decreased glucose-induced insulin release from isolated rat islets. In vivo, vitamin D3 treatment restored the B-cell response within 3 days; this delay suggests an effect of vitamin D3 metabolites. The effect of 1,25-dihydroxyvitamin D3 was studied in vitro on isolated islets from vitamin D3 deficient rats. When it was added to the incubation medium, it increased in a dose-dependent manner islet insulin secretion. However this effect only occurred when the vitamin D3-deficient rats received at least a single injection of vitamin D3 24 hours earlier; these results sustain the hypothesis of a direct but delayed in vitro stimulation of B cell function by 1,25-dihydroxyvitamin D3.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0338-1684
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Direct in vitro effect of 1,25-dihydroxyvitamin D3 on islets insulin secretion in vitamin deficient rats: influence of vitamin D3 pretreatment.
pubmed:affiliation
Laboratoire d'Endocrinologie, Université de Bordeaux I, Talence, France.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't