| pubmed-article:2544249 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2544249 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:2544249 | lifeskim:mentions | umls-concept:C0027708 | lld:lifeskim |
| pubmed-article:2544249 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:2544249 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2544249 | lifeskim:mentions | umls-concept:C0015737 | lld:lifeskim |
| pubmed-article:2544249 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2544249 | pubmed:dateCreated | 1989-7-28 | lld:pubmed |
| pubmed-article:2544249 | pubmed:abstractText | The Third National Wilms' Tumor Study sought to reduce treatment for low-risk patients and find better chemotherapy for those at high risk for relapse. Eligible patients (1439) were randomized according to stage (I-IV) and histology (favorable [FH] or unfavorable [UH]), and contributed data to survival and relapse-free survival (RFS) analyses. Four-year (postnephrectomy) survival percentages and randomized treatment regimens for low-risk patients were 96.5% for 607 Stage I/FH patients who received dactinomycin (Actinomycin D [AMD], Merck Sharp & Dohme, West Point, PA) and vincristine (VCR) for 10 weeks versus 6 months; 92.2% for 278 Stage II/FH patients; and 86.9% for 275 Stage III/FH patients who received AMD + VCR +/- Adriamycin (ADR, Adria Laboratories, Columbus, OH) for 15 months. Stage II/FH patients also had either zero or 2000 cGy irradiation (RT) postoperatively and Stage III/FH patients either 1000 or 2000 cGy. Four-year survival was 73.0% for 279 high-risk patients (any Stage IV, all UH) who received postoperative radiation therapy (RT) and AMD + VCR + ADR +/- cyclophosphamide (CPM). Statistical analysis of survival and RFS experience shows that the less intensive therapy does not worsen results for low-risk patients and CPM does not benefit those at high risk. | lld:pubmed |
| pubmed-article:2544249 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544249 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2544249 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544249 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2544249 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2544249 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2544249 | pubmed:issn | 0008-543X | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:BreslowNN | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:JonesBB | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:BaumHH | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:D'AngioG JGJ | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:EvansAA | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:HrabovskyEE | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:BeckwithJ BJB | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:FernbachDD | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:KelalisPP | lld:pubmed |
| pubmed-article:2544249 | pubmed:author | pubmed-author:deLorimierAA | lld:pubmed |
| pubmed-article:2544249 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2544249 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2544249 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:2544249 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2544249 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:2544249 | pubmed:pagination | 349-60 | lld:pubmed |
| pubmed-article:2544249 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2544249 | pubmed:meshHeading | pubmed-meshheading:2544249-... | lld:pubmed |
| pubmed-article:2544249 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2544249 | pubmed:articleTitle | Treatment of Wilms' tumor. Results of the Third National Wilms' Tumor Study. | lld:pubmed |
| pubmed-article:2544249 | pubmed:affiliation | Children's Cancer Research Center, Children's Hospital, Philadelphia, PA 19104. | lld:pubmed |
| pubmed-article:2544249 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2544249 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2544249 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2544249 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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