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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4911
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pubmed:dateCreated |
1989-7-24
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pubmed:abstractText |
The multiprotein-DNA complexes that participate in bacteriophage lambda site-specific recombination were used to study the combined effect of protein-induced bending and protein-mediated looping of DNA. The protein integrase (Int) is a monomer with two autonomous DNA binding domains of different sequence specificity. Stimulation of Int binding and cleavage at the low affinity core-type DNA sites required interactions with the high affinity arm-type sites and depended on simultaneous binding of the sequence-specific DNA bending protein IHF (integration host factor). The bivalent DNA binding protein is positioned at high affinity sites and directed, by a DNA bending protein, to interactions with distant lower affinity sites. Assembly of this complex is independent of protein-protein interactions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-212715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-226979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2821402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2822395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2831189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2836392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2838756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2842765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2843292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2936603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2943018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2951525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2958633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2964274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2972993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-2975338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3016284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3019560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3031315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3040260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3050531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3277720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3281259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3301328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-331474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3353710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3555843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3656441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3748156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-3948245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-4041012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6089170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6218502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6235918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6246439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6297783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6310548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6317202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6323997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2544029-6457725
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Nucleotidyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Restriction Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Transposable Elements,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Integration Host Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
244
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1457-61
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:2544029-Bacterial Proteins,
pubmed-meshheading:2544029-Bacteriophage lambda,
pubmed-meshheading:2544029-Binding Sites,
pubmed-meshheading:2544029-DNA, Bacterial,
pubmed-meshheading:2544029-DNA, Viral,
pubmed-meshheading:2544029-DNA Nucleotidyltransferases,
pubmed-meshheading:2544029-DNA Restriction Enzymes,
pubmed-meshheading:2544029-DNA Transposable Elements,
pubmed-meshheading:2544029-DNA-Binding Proteins,
pubmed-meshheading:2544029-Integrases,
pubmed-meshheading:2544029-Integration Host Factors,
pubmed-meshheading:2544029-Mutation,
pubmed-meshheading:2544029-Nucleic Acid Conformation,
pubmed-meshheading:2544029-Recombination, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
DNA looping generated by DNA bending protein IHF and the two domains of lambda integrase.
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pubmed:affiliation |
Division of Biology and Medicine, Brown University, Providence, RI 02912.
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pubmed:publicationType |
Journal Article
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