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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1989-7-21
|
| pubmed:abstractText |
The pattern of human papillomavirus type 16 (HPV-16) integration was studied in 23 invasive carcinomas of the cervix using subgenomic probes. Seventeen tumours contained integrated HPV-16 and in 13 of these there was evidence of disruption within the E1-E2 open reading frames (ORFs). In all cases the upstream regulatory region (URR)-E6-E7 ORFs was maintained intact. Two independently derived tumours were infected with episomal wild-type HPV-16 and an episomal variant of HPV-16 containing a 325 bp deletion within the URR (positions 7598 to 17) and a point mutation at position 20 (A to C). This is the first report of a variant HPV-16 which is likely to be both defective and transmissible. Loss of E2 expression and deletion of a large portion of the URR may be two of the mechanisms leading to altered HPV-16 early gene expression in cervical tumours.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1317
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70 ( Pt 4)
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
999-1004
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2543768-Adenocarcinoma,
pubmed-meshheading:2543768-Autoradiography,
pubmed-meshheading:2543768-Blotting, Southern,
pubmed-meshheading:2543768-Carcinoma, Squamous Cell,
pubmed-meshheading:2543768-Cloning, Molecular,
pubmed-meshheading:2543768-DNA, Viral,
pubmed-meshheading:2543768-DNA Probes, HPV,
pubmed-meshheading:2543768-Electrophoresis, Agar Gel,
pubmed-meshheading:2543768-Female,
pubmed-meshheading:2543768-Gene Amplification,
pubmed-meshheading:2543768-Gene Expression Regulation,
pubmed-meshheading:2543768-Humans,
pubmed-meshheading:2543768-Mutation,
pubmed-meshheading:2543768-Nucleic Acid Hybridization,
pubmed-meshheading:2543768-Papillomaviridae,
pubmed-meshheading:2543768-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:2543768-Restriction Mapping,
pubmed-meshheading:2543768-Tumor Virus Infections,
pubmed-meshheading:2543768-Uterine Cervical Neoplasms
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
A novel deletion within the upstream regulatory region of episomal human papillomavirus type 16.
|
| pubmed:affiliation |
Ludwig Institute for Cancer Research, St Mary's Hospital Medical School, London, U.K.
|
| pubmed:publicationType |
Journal Article
|