Linked Life Data

2543004

Source:http://linkedlifedata.com/resource/pubmed/id/2543004

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-7-7
pubmed:abstractText
The female rat exhibits elevated corticosterone levels throughout lactation, suggesting a possible dampening of the sensitivity of adrenocortical negative-feedback processes during this period. Negative-feedback within the adrenocortical axis is, in large part, mediated by an enhanced hormone receptor signal at a number of glucocorticoid target sites, including the pituitary, hypothalamus, and hippocampus. In the study reported here we have measured glucocorticoid receptor binding capacity in soluble fractions prepared from these tissues, using an in vitro binding assay with [3H]dexamethasone as radioligand. We found that during at least the first two weeks of lactation the rat shows significantly decreased [3H]dexamethasone binding capacity in the hippocampus, with no change in pituitary or the hypothalamus during lactation. These data provide one possible mechanism whereby a critical target region for adrenocortical negative-feedback might be desensitized to circulating glucocorticoids, thus permitting the sustained elevation in pituitary-adrenal activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Glucocorticoid receptors in brain and pituitary of the lactating rat.
pubmed:affiliation
Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't