|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1989-7-12
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The T-cell receptor (TCR) alpha/delta chain locus on chromosome 14q11 is nonrandomly involved in translocations and inversions in human T-cell neoplasms. We have analyzed three acute T-lymphoblastic leukemia samples carrying a t(10;14)(q24;q11) chromosome translocation by means of somatic cell hybrids and molecular cloning. In all cases studied the translocation splits the TCR delta chain locus. Somatic cell hybrids containing the human 10q+ chromosome resulting from the translocation retain the human terminal deoxynucleotidyltransferase gene mapped at 10q23-q24 and the diversity and joining, D delta 2-J delta 1, regions of the TCR delta chain, but not the V alpha region (variable region of the TCR alpha chain), demonstrating that the split occurred within the V alpha-D delta 2 region. Molecular cloning of the breakpoint junctions revealed that the TCR delta chain sequences involved are made from the D delta 2 segment. The chromosome breakpoints are clustered within a region of approximately 263 base pairs of chromosome 10. The results suggest that the translocation of the TCR delta chain locus to a locus on 10q, which we have designated TCL3, results in deregulation of this putative oncogene, leading to acute T-cell leukemia.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-2439914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-2836865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-2885838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3097550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3110950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3259177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3416831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3485458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3490692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3499667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3862101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3875152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3919442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-3923362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-6327071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-6336310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-6417658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-6424112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-6438800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-6609313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542965-6700731
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
86
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4161-5
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2542965-Base Sequence,
pubmed-meshheading:2542965-Chromosome Aberrations,
pubmed-meshheading:2542965-Chromosome Disorders,
pubmed-meshheading:2542965-Chromosomes, Human, Pair 10,
pubmed-meshheading:2542965-Chromosomes, Human, Pair 14,
pubmed-meshheading:2542965-Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,
pubmed-meshheading:2542965-Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor,
pubmed-meshheading:2542965-Humans,
pubmed-meshheading:2542965-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:2542965-Molecular Sequence Data,
pubmed-meshheading:2542965-Receptors, Antigen, T-Cell,
pubmed-meshheading:2542965-Restriction Mapping,
pubmed-meshheading:2542965-Translocation, Genetic
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation.
|
|
pubmed:affiliation |
Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
