Linked Life Data

2542956

Source:http://linkedlifedata.com/resource/pubmed/id/2542956

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1989-6-28
pubmed:abstractText
Endothelin is a potent endothelium-derived vasoconstrictor peptide recently characterized from porcine and human vascular endothelial cells. Here we provide evidence that endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in porcine coronary artery smooth muscle. The vasoconstrictor action of endothelin is efficiently antagonized by low doses of the dihydropyridine Ca2+-channel blocker nicardipine. Endothelin augments the Ca2+-induced contraction in a high-K+ depolarizing solution, markedly enhances high-threshold Ca2+-channel current on the whole-cell patch clamp recording, and causes a sustained increase in the intracellular Ca2+ that is largely dependent on extracellular Ca2+. These findings suggest that endothelin exerts its vasoconstrictor effect by either directly or indirectly activating the voltage-dependent Ca2+ channel.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-14009454, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2410796, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2432624, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2439228, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2439545, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2440051, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2446390, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2448467, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2450476, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2451132, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2452033, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2453389, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2454449, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-2902806, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-3010126, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-3022313, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-3034140, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-3034448, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-3045827, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-3282927, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-37533, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-6095092, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-6131381, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-6190088, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-6209390, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-6232463, http://linkedlifedata.com/resource/pubmed/commentcorrection/2542956-6270629
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3915-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.
pubmed:affiliation
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't