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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1989-6-27
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pubmed:abstractText |
We describe novel mutants of herpes simplex virus which are resistant to aphidicolin. Their mutant phenotypes suggest that they encode DNA polymerases with altered substrate recognition. This conclusion is based on their abnormal sensitivity to polymerase inhibitors and to the abnormal mutation rates exhibited by two of the mutants.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-2842788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-2987953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-2991710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-3015009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-3027369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-3034575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-3072719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-3131016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-450707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-467434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-482131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6092371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6167579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6250617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6280605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6313660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6320535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6328755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6402775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-6784928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-7356466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-81050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2542598-88745
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2874-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2542598-Antiviral Agents,
pubmed-meshheading:2542598-Aphidicolin,
pubmed-meshheading:2542598-Cloning, Molecular,
pubmed-meshheading:2542598-DNA, Viral,
pubmed-meshheading:2542598-DNA-Directed DNA Polymerase,
pubmed-meshheading:2542598-Diterpenes,
pubmed-meshheading:2542598-Drug Resistance, Microbial,
pubmed-meshheading:2542598-Mutation,
pubmed-meshheading:2542598-Phenotype,
pubmed-meshheading:2542598-Restriction Mapping,
pubmed-meshheading:2542598-Simplexvirus,
pubmed-meshheading:2542598-Substrate Specificity,
pubmed-meshheading:2542598-Viral Plaque Assay
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pubmed:year |
1989
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pubmed:articleTitle |
Aphidicolin resistance in herpes simplex virus type 1 appears to alter substrate specificity in the DNA polymerase.
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pubmed:affiliation |
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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