Linked Life Data

2542518

Source:http://linkedlifedata.com/resource/pubmed/id/2542518

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-7-10
pubmed:abstractText
Sites of the inhibitory actions of antiallergic and antihistaminic drugs on polymorphonuclear leukocytes were examined by means of measurements of arachidonic acid release, superoxide anion generation and changes in membrane potential. The results obtained in this study were as follows. (i) Azelastine, an antiallergic drug, inhibited arachidonic acid release as well as superoxide generation. However, high concentrations of azelastine diminished the charge of the cells. (ii) Clemastine, used as an antihistamine, was as effective as azelastine on the metabolic bursts of leukocytes, including changes of membrane potential in leukocytes. (iii) The selective inhibition of arachidonic acid release was achieved by ketotifen without appreciable effect on superoxide generation. The relationship among the changes of membrane potential, superoxide generation and arachidonic acid release is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0386-846X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Inhibitions of metabolic responses of polymorphonuclear leukocytes by antiallergic drugs.
pubmed:affiliation
Department of Toxicology, Niigata College of Pharmacy, Japan.
pubmed:publicationType
Journal Article, In Vitro