| pubmed-article:2542404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2542404 | lifeskim:mentions | umls-concept:C0806987 | lld:lifeskim |
| pubmed-article:2542404 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:2542404 | lifeskim:mentions | umls-concept:C0074479 | lld:lifeskim |
| pubmed-article:2542404 | lifeskim:mentions | umls-concept:C1326120 | lld:lifeskim |
| pubmed-article:2542404 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2542404 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2542404 | pubmed:dateCreated | 1989-7-6 | lld:pubmed |
| pubmed-article:2542404 | pubmed:abstractText | CD43 (sialophorin, gpL115) is a sialoglycoprotein expressed on a wide variety of blood cells including lymphocytes, monocytes, neutrophils, and platelets. L10, an anti-CD43 mAb, has been shown to induce monocyte-dependent activation and proliferation of human T lymphocytes. We have studied the signaling mechanism involved in this activation process. Treatment of PBMC and purified populations of T cells and monocytes with L10 induced the hydrolysis of phosphoinositides with the resultant generation of the phosphoinositide-derived second messengers diacylglycerol and inositol phosphates. This was associated with the translocation of protein kinase C from cytosol to membrane fractions and an increase in free intracellular Ca2+ in treated cells. In human leukemic T cell lines, the magnitude of signaling via CD43 did not correlate with the density of the TCR/CD3 surface expression nor with the intensity of signaling via the TCR/CD3. Moreover, a mutant derived from the leukemic T cell line HPB-ALL that was severely defective in TCR/CD3 surface expression and signaling nevertheless had normal CD43 surface expression and signaling compared with the parent cell line. It is concluded that CD43 is functionally coupled to the phospholipase C/phosphoinositides signaling pathway. In human T cells, signaling via CD43 proceeds independently of TCR/CD3. The widespread expression of CD43 suggests a potentially important role for this molecule in orchestrating the activation of multiple cell types. | lld:pubmed |
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| pubmed-article:2542404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2542404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2542404 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2542404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2542404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2542404 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2542404 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:RosenFF | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:GehaRR | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:TerhorstCC | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:WongR CRC | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:VercelliDD | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:SanchoJJ | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:Remold-O'Donn... | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:ChatilaTT | lld:pubmed |
| pubmed-article:2542404 | pubmed:author | pubmed-author:SilvermanL... | lld:pubmed |
| pubmed-article:2542404 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2542404 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2542404 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:2542404 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2542404 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2542404 | pubmed:pagination | 4194-200 | lld:pubmed |
| pubmed-article:2542404 | pubmed:dateRevised | 2011-9-7 | lld:pubmed |
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| pubmed-article:2542404 | pubmed:meshHeading | pubmed-meshheading:2542404-... | lld:pubmed |
| pubmed-article:2542404 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2542404 | pubmed:articleTitle | Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. | lld:pubmed |
| pubmed-article:2542404 | pubmed:affiliation | Division of Allergy and Immunology, Children's Hospital, Boston, MA 02115. | lld:pubmed |
| pubmed-article:2542404 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2542404 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2542404 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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