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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
1989-7-7
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pubmed:abstractText |
The effects of peripheral benzodiazepines on the respiration of a neuronal cell, the mouse C 1300 neuroblastoma, were analyzed. The presence of 'peripheral receptors' to the [3H]PK 11195 ligand was checked in these cells. A dose-dependent decrease of the O2 consumption in the presence of Ro 5-4864 and PK 11195 was observed at concentrations consistent with a receptor-mediated action. Diazepam, clonazepam and Ro 15-1788 were inactive. Previous studies have localized the peripheral benzodiazepine receptors on the mitochondrial outer membrane. We report here an effect of the peripheral ligand on mitochondrial metabolism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-202
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2542045-Animals,
pubmed-meshheading:2542045-Benzodiazepines,
pubmed-meshheading:2542045-Cells, Cultured,
pubmed-meshheading:2542045-Clonazepam,
pubmed-meshheading:2542045-Clone Cells,
pubmed-meshheading:2542045-Diazepam,
pubmed-meshheading:2542045-Flumazenil,
pubmed-meshheading:2542045-Isoquinolines,
pubmed-meshheading:2542045-Mice,
pubmed-meshheading:2542045-Mitochondria,
pubmed-meshheading:2542045-Neuroblastoma,
pubmed-meshheading:2542045-Oxygen Consumption,
pubmed-meshheading:2542045-Receptors, GABA-A
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pubmed:year |
1989
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pubmed:articleTitle |
Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells.
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pubmed:affiliation |
Laboratoire de Biochimie Cellulaire, Collège de France, Paris, France.
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pubmed:publicationType |
Journal Article
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