Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-6-14
pubmed:abstractText
Single channel currents flowing through Na channels were studied in cell-attached patches from guinea-pig ventricular myocytes after removal of the fast component of inactivation by the S enantiomer of DPI 201-106. In addition to openings with a single channel conductance of 15 pS, two other types of events occur. A low conductance state has a single channel conductance of 5 pS, while a medium conductance state can sometimes be seen at 8 pS. These different conductance states can coexist in the same patch. The low conductance state appears to have the same kinetic properties as the high conductance state. However it is less sensitive to block by TTX. Averaged currents obtained from exclusively low conductance openings also show a decay (time constant at -30 mV of 0.8 +/- 0.4 s) which is not significantly different from the decay of the high conductance channel. The average open and closed times are also similar to the values for the high conductance channel. The medium conductance state has a single channel conductance of 8 pS and a reversal potential which is similar to the high conductance channel. Closings of the high conductance state to the medium conductance state can be observed as well as openings from the medium to the high conductance state. The average current of sweeps showing only the medium conductance state has the same time course and shows a similar TTX-sensitivity as the average current of the high conductance state. Also the voltage range for steady-state activation and inactivation for the medium conductance channel matches that of the high conductance channel.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
413
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
242-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Different conductance states of the bursting Na channel in guinea-pig ventricular myocytes.
pubmed:affiliation
Laboratory of Physiology, Leuven, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't