Linked Life Data

2541258

Source:http://linkedlifedata.com/resource/pubmed/id/2541258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-6-12
pubmed:abstractText
The effects of acidosis (pH 6.5) on the efflux of noradrenaline from the perfused heart of the rat have been studied. Acidosis does not influence the noradrenaline efflux induced by sympathetic nerve stimulation either in the presence or absence of neuronal uptake blockade. It is therefore unlikely that acidosis will contribute to the failure of nerve stimulation mediated noradrenaline release previously shown to occur during myocardial ischaemia. Acidosis exerts a biphasic effect on the noradrenaline efflux produced by substrate free anoxic perfusion with an inhibition of early noradrenaline overflow. Peak anoxic efflux of noradrenaline is greater when extracellular NaCl is replaced by Tris or sucrose in keeping with the hypothesis of carrier-mediated noradrenaline efflux. Marked early anoxic efflux occurs when extracellular NaCl is replaced by LiCl suggesting an additional mechanism of vesicular destabilization. Anoxic noradrenaline efflux is inhibited by amiloride (and ethylisopropyl amiloride) and it is proposed that the inhibitory effect of extracellular acidosis on early noradrenaline efflux also occurs by inhibition of the Na+ (Li+)/H+ antiporter leading to reduced Na+ (Li+) entry during the early phase of anoxia. At a later stage acidosis enhances anoxic noradrenaline efflux. This effect is postulated to be due to a reduction in the transvesicular pH gradient available for catecholamine storage within the storage vesicles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effects of acidosis on anoxic and exocytotic noradrenaline release from the heart.
pubmed:affiliation
Department of Medicine, University of Edinburgh, Scotland, UK.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't