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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-6-22
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pubmed:abstractText |
The reactions to and antigenicity of two human-rhesus rotavirus (RRV) reassortants (human rotavirus strain D x RRV and human rotavirus strain DS1 x RRV) with the VP7 neutralization specificity of a serotype 1 or serotype 2 rotavirus were evaluated in a placebo-controlled double-blind trial in 116 1- to 5-month-old infants in Caracas, Venezuela. The children were randomly divided into five groups to receive orally the following inocula: (i) 10(4) PFU of D x RRV reassortant; (ii) 10(4) PFU of DS1 x RRV reassortant; (iii) 10(4) PFU of RRV; (iv) 5 x 10(3) PFU of D x RRV and 5 x 10(3) PFU of RRV; and (v) placebo. The children were examined daily for 7 days following vaccine administration; 8 to 26% of the vaccinated infants developed a mild febrile reaction which in most cases lasted only 1 day. Seroresponses to rotavirus were observed in 39 to 65% of the vaccinees by plaque neutralization assay and in 57 to 88% by an immunoglobulin A enzyme-linked immunosorbent assay. Vaccine shedding was detected in 53 to 86% of the vaccinees. Analysis of neutralization antibody responses indicates that the VP4 protein represents an important component of the response induced by the vaccines.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-2422398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-2839813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-2873370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-2874413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-2882289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-2884455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-2983101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-3001716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-3009632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-3009634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-3021814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-3027196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-3033090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-3876173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-3894608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-6143964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-6202807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-6286486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-6311872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2541168-6321551
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
512-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2541168-Age Factors,
pubmed-meshheading:2541168-Antibodies, Viral,
pubmed-meshheading:2541168-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2541168-Follow-Up Studies,
pubmed-meshheading:2541168-Humans,
pubmed-meshheading:2541168-Immunoglobulin A,
pubmed-meshheading:2541168-Infant,
pubmed-meshheading:2541168-Neutralization Tests,
pubmed-meshheading:2541168-Random Allocation,
pubmed-meshheading:2541168-Rotavirus,
pubmed-meshheading:2541168-Vaccines, Synthetic,
pubmed-meshheading:2541168-Venezuela,
pubmed-meshheading:2541168-Viral Vaccines
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pubmed:year |
1989
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pubmed:articleTitle |
Reactions to and antigenicity of two human-rhesus rotavirus reassortant vaccine candidates of serotypes 1 and 2 in Venezuelan infants.
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pubmed:affiliation |
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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