| pubmed-article:2540884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2540884 | lifeskim:mentions | umls-concept:C0013080 | lld:lifeskim |
| pubmed-article:2540884 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:2540884 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:2540884 | lifeskim:mentions | umls-concept:C2611044 | lld:lifeskim |
| pubmed-article:2540884 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:2540884 | pubmed:dateCreated | 1989-6-15 | lld:pubmed |
| pubmed-article:2540884 | pubmed:abstractText | The binding of D-[3H]aspartate to glutamate uptake sites was measured in post-mortem brains from subjects with Down's syndrome (DS) and age-matched controls. DS brains had substantially reduced D-[3H]aspartate binding in the frontal and temporal cortex, hippocampus and caudate nucleus. There was no correlation between the numbers of Alzheimer-like plaques and tangles or clinically-assessed dementia and D-[3H]aspartate binding in DS brains. The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine ([3H]TCP) to postsynaptic N-methyl-D-aspartate sites was normal in DS brains. This study suggests that the reduction in glutamate uptake sites in DS is more substantial and widespread than in Alzheimer's disease. | lld:pubmed |
| pubmed-article:2540884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2540884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2540884 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2540884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2540884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2540884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2540884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2540884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2540884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2540884 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2540884 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2540884 | pubmed:author | pubmed-author:DeakinJ FJF | lld:pubmed |
| pubmed-article:2540884 | pubmed:author | pubmed-author:SlaterPP | lld:pubmed |
| pubmed-article:2540884 | pubmed:author | pubmed-author:ReynoldsG PGP | lld:pubmed |
| pubmed-article:2540884 | pubmed:author | pubmed-author:CrossA JAJ | lld:pubmed |
| pubmed-article:2540884 | pubmed:author | pubmed-author:MannD MDM | lld:pubmed |
| pubmed-article:2540884 | pubmed:author | pubmed-author:SimpsonM DMD | lld:pubmed |
| pubmed-article:2540884 | pubmed:author | pubmed-author:RoystonM CMC | lld:pubmed |
| pubmed-article:2540884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2540884 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:2540884 | pubmed:volume | 484 | lld:pubmed |
| pubmed-article:2540884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2540884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2540884 | pubmed:pagination | 273-8 | lld:pubmed |
| pubmed-article:2540884 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:meshHeading | pubmed-meshheading:2540884-... | lld:pubmed |
| pubmed-article:2540884 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2540884 | pubmed:articleTitle | Reduced D-[3H]aspartate binding in Down's syndrome brains. | lld:pubmed |
| pubmed-article:2540884 | pubmed:affiliation | Departments of Physiological Sciences, University of Manchester Medical School, U.K. | lld:pubmed |
| pubmed-article:2540884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2540884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
