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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1989-6-15
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pubmed:abstractText |
The binding of D-[3H]aspartate to glutamate uptake sites was measured in post-mortem brains from subjects with Down's syndrome (DS) and age-matched controls. DS brains had substantially reduced D-[3H]aspartate binding in the frontal and temporal cortex, hippocampus and caudate nucleus. There was no correlation between the numbers of Alzheimer-like plaques and tangles or clinically-assessed dementia and D-[3H]aspartate binding in DS brains. The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine ([3H]TCP) to postsynaptic N-methyl-D-aspartate sites was normal in DS brains. This study suggests that the reduction in glutamate uptake sites in DS is more substantial and widespread than in Alzheimer's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
484
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2540884-Aged,
pubmed-meshheading:2540884-Aspartic Acid,
pubmed-meshheading:2540884-Brain,
pubmed-meshheading:2540884-Child,
pubmed-meshheading:2540884-Down Syndrome,
pubmed-meshheading:2540884-Humans,
pubmed-meshheading:2540884-Middle Aged,
pubmed-meshheading:2540884-Phencyclidine,
pubmed-meshheading:2540884-Receptors, Glutamate,
pubmed-meshheading:2540884-Receptors, Neurotransmitter
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pubmed:year |
1989
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pubmed:articleTitle |
Reduced D-[3H]aspartate binding in Down's syndrome brains.
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pubmed:affiliation |
Departments of Physiological Sciences, University of Manchester Medical School, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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