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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-5-23
|
| pubmed:abstractText |
We herein propose that specific chromosomal aberrations associated with specific neoplasms are not necessarily inherited as a constitutional trait. High-risk individuals may have a tendency to undergo specific somatic mutations or chromosomal rearrangements at a relatively low frequency in all tissues as mosaicism. This may potentiate the development of specific somatic cancers. Our hypothesis may be applicable to both hereditary and sporadic types of neoplasms.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0250-7005
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
17-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2539769-Aged,
pubmed-meshheading:2539769-Carcinoma, Renal Cell,
pubmed-meshheading:2539769-Disease Susceptibility,
pubmed-meshheading:2539769-Humans,
pubmed-meshheading:2539769-Kidney Neoplasms,
pubmed-meshheading:2539769-Male,
pubmed-meshheading:2539769-Mosaicism,
pubmed-meshheading:2539769-Neoplasms,
pubmed-meshheading:2539769-Wilms Tumor
|
| pubmed:articleTitle |
Genetic susceptibility, somatic mosaicisms and predisposition to human cancer.
|
| pubmed:affiliation |
Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|