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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-5-18
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pubmed:abstractText |
Rabbit antisera raised against human FYN-specific peptides were used to evaluate the expression of the fyn gene product in normal and murine polyomavirus middle tumor antigen (MTAg)-transformed rat cells. The antisera were capable of detecting p60fyn in both normal and MTAg-transformed cells. Two different antisera directed against unique p60fyn sequences were found to detect p60fyn-MTAg complexes in cell lysates from the MTAg-transformed cells. The MTAg molecules immunoprecipitated by FYN antisera were phosphorylated on tyrosine during immune-complex kinase reactions at sites similar to those found on MTAg in complexes with pp60c-src. Whereas the abundance of p60fyn was estimated to be less in the MTAg-transformed cells than in their normal counterparts, the specific activities of p60fyn molecules in the normal and transformed cells were similar.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2411538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2426573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2426575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2431289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2433463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2442413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2454396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2463167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-2981329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-3011402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-3027584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-3061807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-3099169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-3262426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-3287380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-3315000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-3526330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-6091900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-6265803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-6304524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-6312092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539523-6325177
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2343-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2539523-Amino Acid Sequence,
pubmed-meshheading:2539523-Animals,
pubmed-meshheading:2539523-Antigens, Polyomavirus Transforming,
pubmed-meshheading:2539523-Blotting, Western,
pubmed-meshheading:2539523-Cell Line, Transformed,
pubmed-meshheading:2539523-Cell Transformation, Viral,
pubmed-meshheading:2539523-Cross Reactions,
pubmed-meshheading:2539523-Molecular Weight,
pubmed-meshheading:2539523-Peptide Mapping,
pubmed-meshheading:2539523-Phosphoproteins,
pubmed-meshheading:2539523-Polyomavirus,
pubmed-meshheading:2539523-Precipitin Tests,
pubmed-meshheading:2539523-Protein Binding,
pubmed-meshheading:2539523-Protein-Tyrosine Kinases,
pubmed-meshheading:2539523-Proto-Oncogene Proteins,
pubmed-meshheading:2539523-Proto-Oncogene Proteins c-fyn,
pubmed-meshheading:2539523-Rats
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pubmed:year |
1989
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pubmed:articleTitle |
Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells.
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pubmed:affiliation |
Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article
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