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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-5-18
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pubmed:abstractText |
Helper virus-free Abelson murine leukemia virus (A-MuLV) was used to induce monoclonal pre-B-cell tumors in mice. The clonality, patterns of immunoglobulin heavy-chain gene rearrangement, tumorigenicity, and v-abl oncogene expression in individual preleukemic and leukemic colonies were compared. Our results indicate that A-MuLV preleukemic cells with low or undetectable tumorigenic potential give rise to leukemic cells with high tumorigenic potential by a process of subclone selection. The levels of v-abl oncogene product in preleukemic and leukemic cell populations were not significantly different. These results suggest that an additional event(s) unrelated to the level of the v-abl protein product is required for A-MuLV-transformed cells to become fully malignant.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-163444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-163975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-178822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-222460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-2434953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-2825174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-2838788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-2845118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-3016297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-3032456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-3035219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-3039515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-3041046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-3906410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-4099080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6202819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6244493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6250219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6257926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6262813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6275106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6276010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6277505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6294342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6304498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6308472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6308473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539498-6608556
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1989-94
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2539498-Abelson murine leukemia virus,
pubmed-meshheading:2539498-Animals,
pubmed-meshheading:2539498-Blotting, Southern,
pubmed-meshheading:2539498-Cell Division,
pubmed-meshheading:2539498-Clone Cells,
pubmed-meshheading:2539498-DNA, Neoplasm,
pubmed-meshheading:2539498-Gene Expression Regulation,
pubmed-meshheading:2539498-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:2539498-Leukemia, Experimental,
pubmed-meshheading:2539498-Leukemia Virus, Murine,
pubmed-meshheading:2539498-Mice,
pubmed-meshheading:2539498-Oncogene Proteins, Viral,
pubmed-meshheading:2539498-Preleukemia
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pubmed:year |
1989
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pubmed:articleTitle |
Multiple steps are required for the induction of tumors by Abelson murine leukemia virus.
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pubmed:affiliation |
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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