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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-5-11
|
| pubmed:abstractText |
Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
31
|
| pubmed:volume |
159
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1128-34
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2539141-Animals,
pubmed-meshheading:2539141-DNA Damage,
pubmed-meshheading:2539141-DNA Topoisomerases, Type II,
pubmed-meshheading:2539141-Escherichia coli,
pubmed-meshheading:2539141-Models, Theoretical,
pubmed-meshheading:2539141-Plasmids,
pubmed-meshheading:2539141-Pregnenes,
pubmed-meshheading:2539141-Spleen,
pubmed-meshheading:2539141-Swine
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage.
|
| pubmed:affiliation |
Institute of Life Science and National Tsing Hua University, Taiwan, R.O.C.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|