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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1989-4-25
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pubmed:abstractText |
Swiss 3T3 cells were labelled for 36 hours with high levels of 3H-myo-inositol and the radioactivity in nuclear inositol phospholipids was measured. Treatment of cells for 2 minutes, but not for 4 hours, with mitogenic concentrations of insulin-like growth factor I and bombesin caused a slight decrease in PtdIns and more marked decreases in PtdInsP and PtdInsP2. These effects were not seen if isolated nuclei were incubated with IGF-I and bombesin. We interpret these results to mean that rapid mass changes occur in nuclear inositol phospholipids in the early stages of the mitotic response.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
720-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2539123-Animals,
pubmed-meshheading:2539123-Cell Line,
pubmed-meshheading:2539123-Cell Nucleus,
pubmed-meshheading:2539123-Fibroblasts,
pubmed-meshheading:2539123-Inositol Phosphates,
pubmed-meshheading:2539123-Insulin-Like Growth Factor I,
pubmed-meshheading:2539123-Mice,
pubmed-meshheading:2539123-Phosphatidylinositols,
pubmed-meshheading:2539123-Somatomedins
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pubmed:year |
1989
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pubmed:articleTitle |
Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor I.
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pubmed:affiliation |
Istituto di Morfologia Umana Normale, University of Chieti, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|