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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-4-28
|
| pubmed:abstractText |
The hypothesis according to which botulinum A toxin blocks acetylcholine release from motor endings by stimulating intracellular Ca2+ disposal systems was tested by recording presynaptic membrane currents from poisoned muscles. Calcium and calcium-activated potassium currents displayed amplitudes, time courses and stimulation frequency-dependent inactivation similar to those observed in unpoisoned preparations. This indicates that poisoned endings are no more efficient than normal ones in dealing with Ca2+ overloads.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
479
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
167-71
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:2538205-Animals,
pubmed-meshheading:2538205-Botulinum Toxins,
pubmed-meshheading:2538205-Calcium,
pubmed-meshheading:2538205-Calcium Channels,
pubmed-meshheading:2538205-Male,
pubmed-meshheading:2538205-Membrane Potentials,
pubmed-meshheading:2538205-Motor Neurons,
pubmed-meshheading:2538205-Neuromuscular Junction,
pubmed-meshheading:2538205-Potassium,
pubmed-meshheading:2538205-Rana esculenta
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Is the internal calcium regulation altered in type A botulinum toxin-poisoned motor endings?
|
| pubmed:affiliation |
Laboratoire de Neurobiologie Cellulaire et Moléculaire, C.N.R.S., Gif sur Yvette, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|