Linked Life Data

2538132

Source:http://linkedlifedata.com/resource/pubmed/id/2538132

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-4-24
pubmed:abstractText
In this article we report the results of two experiments examining the role of central benzodiazepine receptor sites in the response to novelty. Animals that were food deprived and presented with food in a novel environment showed long latencies before they began eating. Pretreatment with diazepam or preexposure to the "novel" environment for 1 hr/day for 4 or 7 days before testing in that environment dramatically reduced the latency to begin eating. Administration of either the "inverse agonist," FG-7142, or an antagonist, RO15-1788, of the central benzodiazepine receptor before testing completely reversed the effects of 7 days of preexposure to the novel environment. In home-cage feeding tests, FG-7142, but not RO15-1788, increased the latency to begin feeding in food-deprived animals. These findings indicate that FG-7142 is strongly anxiogenic, whereas RO15-1788 is not anxiogenic, yet both drugs are potent in reversing the effects of habituation. The results of these experiments suggest that the normal process of habituation to novelty may involve the release of an endogenous, anxiolytic compound (an agonist) that binds to a central benzodiazepine receptor, the effects of which are blocked by RO15-1788.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0735-7044
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Role of the central benzodiazepine receptor system in behavioral habituation to novelty.
pubmed:affiliation
Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't