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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1989-4-3
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pubmed:abstractText |
A multicenter, randomized, double-blind assessment of 130 patients with congestive heart failure (New York Heart Association functional classes II to IV) was undertaken to assess the therapeutic efficacy of lisinopril, an angiotensin-converting enzyme inhibitor. All the subjects received concurrent therapy with digoxin and diuretics. Assessments performed periodically over 12 weeks revealed that the active treatment was associated with significant improvements in treadmill exercise time, cardiothoracic ratio, ejection fraction, functional status and clinical signs and symptoms of heart failure. Lisinopril exhibited a mild first-dose effect on blood pressure that was not significantly different from that observed with placebo. The incidence of adverse experiences was not markedly different in the 2 study groups, with only mild hypotension and dizziness occurring more frequently in association with the active medication.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-9149
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12D-16D
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2537560-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:2537560-Blood Pressure,
pubmed-meshheading:2537560-Cardiac Output,
pubmed-meshheading:2537560-Clinical Trials as Topic,
pubmed-meshheading:2537560-Double-Blind Method,
pubmed-meshheading:2537560-Dyspnea,
pubmed-meshheading:2537560-Enalapril,
pubmed-meshheading:2537560-Exercise Test,
pubmed-meshheading:2537560-Fatigue,
pubmed-meshheading:2537560-Heart Failure,
pubmed-meshheading:2537560-Humans,
pubmed-meshheading:2537560-Lisinopril,
pubmed-meshheading:2537560-Multicenter Studies as Topic,
pubmed-meshheading:2537560-Placebos,
pubmed-meshheading:2537560-Random Allocation,
pubmed-meshheading:2537560-Time Factors
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pubmed:year |
1989
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pubmed:articleTitle |
Comparison of lisinopril versus placebo for congestive heart failure.
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pubmed:affiliation |
Department of Cardiology, Napier Hospital, New Zealand.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
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