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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-2-13
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pubmed:abstractText |
The authors determined the pharmacokinetics and duration of action of a bolus dose of pipecuronium bromide (0.07 mg.kg-1) in 40 patients anesthetized with halothane and nitrous oxide. Twenty were patients with normal renal function, undergoing a variety of surgical procedures, and 20 were undergoing cadaver renal transplantation because of end-stage renal disease. Plasma concentrations of pipecuronium were measured for 6 h after administration using a sensitive and specific capillary gas chromatographic assay. Plasma concentration versus time data were analyzed by nonlinear regression and fit to a two-compartment or three-compartment model; in addition, the data were analyzed by a non-compartmental method based on statistical moments. Neuromuscular blockade was assessed by measuring the mechanical evoked response of the adductor pollicis muscle to train-of-four stimulation of the ulnar nerve. The pharmacokinetic parameters derived by compartmental modelling were (normal vs. renal failure, respectively): volume of distribution at steady state (309 +/- 103 vs. 442 +/- 158 ml.kg-1, mean +/- SD), plasma clearance, (2.4 +/- 0.6 vs. 1.6 +/- 0.6 ml.kg-1.min-1), mean residence time (140 +/- 63 vs. 329 +/- 198 min), and elimination half-life (137 +/- 68 vs. 263 +/- 168 min). The same parameters as derived by the non-compartmental method were (normal vs. renal failure, respectively): volume of distribution at steady state (307 +/- 80 vs. 426 +/- 119 ml.kg-1, mean +/- SD), plasma clearance (2.4 +/- 0.6 vs. 1.6 +/- 0.6 ml.kg-1.min-1), mean residence time (134 +/- 41 vs. 323 +/- 228 min), and elimination half-life (118 +/- 35 vs. 247 +/- 168 min).(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Androstane-3,17-diol,
http://linkedlifedata.com/resource/pubmed/chemical/Androstanols,
http://linkedlifedata.com/resource/pubmed/chemical/Halothane,
http://linkedlifedata.com/resource/pubmed/chemical/Neuromuscular Blocking Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrous Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Pipecuronium,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0003-3022
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2536254-Adult,
pubmed-meshheading:2536254-Androstane-3,17-diol,
pubmed-meshheading:2536254-Androstanols,
pubmed-meshheading:2536254-Anesthesia, Inhalation,
pubmed-meshheading:2536254-Chromatography, Gas,
pubmed-meshheading:2536254-Halothane,
pubmed-meshheading:2536254-Humans,
pubmed-meshheading:2536254-Kidney Failure, Chronic,
pubmed-meshheading:2536254-Middle Aged,
pubmed-meshheading:2536254-Neuromuscular Blocking Agents,
pubmed-meshheading:2536254-Nitrous Oxide,
pubmed-meshheading:2536254-Pipecuronium,
pubmed-meshheading:2536254-Piperazines,
pubmed-meshheading:2536254-Time Factors
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pubmed:year |
1989
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pubmed:articleTitle |
The influence of renal failure on the pharmacokinetics and duration of action of pipecuronium bromide in patients anesthetized with halothane and nitrous oxide.
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pubmed:affiliation |
Department of Anesthesia, University of California San Francisco 94143-0648.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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