Linked Life Data

2536250

Source:http://linkedlifedata.com/resource/pubmed/id/2536250

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 2
pubmed:dateCreated
1989-2-23
pubmed:abstractText
In vitro cerebral oxidative metabolism undergoes dramatic increases in infant rats between 10 and 20 days of age. To determine this was also the case in vivo, comparisons were made of cerebral blood flow (CBF) and oxygenation in rats at 10, 20, and 60-90 days of age, under pentobarbital sodium anesthesia. Measurements were made of CBF, arterial and venous O2 content, cerebral PO2 distributions, and the oxidation state of cytochrome-c oxidase (cytochrome aa3). CBF, O2 delivery, and O2 consumption all increased progressively with maturation. In contrast, cerebral PO2, cytochrome aa3 oxidation state, and O2 extraction fraction were higher in 20-day-old rats than in either 10-day-old or adult rats. We attribute this difference primarily to the high density of cerebral capillaries in the 20-day-old rat. We conclude that cerebral tissue PO2 and the oxidation state of cytochrome aa3 are determined by the density of perfused capillaries in addition to the more commonly accepted factors of cerebral O2 delivery and consumption.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
256
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R78-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Cerebral oxygenation and blood flow in infant and young adult rats.
pubmed:affiliation
Department of Physiology, Pharmacology, and Psychiatry, Tulane University School of Medicine, New Orleans, Louisiana 70112.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't