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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2 Pt 1
|
| pubmed:dateCreated |
1989-2-22
|
| pubmed:abstractText |
Recurrence of hepatocellular carcinoma after treatment is frequent. To study the clonal origin of the recurrent tumors, we examined five pairs of hepatocellular carcinomas resected from individual hepatitis B surface antigen carriers. Using integrated hepatitis B virus DNA as a marker, tumor clonality was determined by Southern blot analysis. In 2 cases the second tumor contained the same integrated viral DNA as the first one. In the other 3 cases, the clonality of the second cancer differed. We conclude that recurrent hepatocellular carcinomas originate from the first tumor in some cases but represent de novo neoplasms in others.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0016-5085
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
96
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
527-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2535996-Base Sequence,
pubmed-meshheading:2535996-Blotting, Southern,
pubmed-meshheading:2535996-Carcinoma, Hepatocellular,
pubmed-meshheading:2535996-Cell Line,
pubmed-meshheading:2535996-DNA, Viral,
pubmed-meshheading:2535996-Hepatitis B virus,
pubmed-meshheading:2535996-Humans,
pubmed-meshheading:2535996-Liver Neoplasms,
pubmed-meshheading:2535996-Neoplasm Recurrence, Local
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Clonal origin of recurrent hepatocellular carcinomas.
|
| pubmed:affiliation |
Department of Internal Medicine, National Taiwan University College of Medicine, Taipei.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|