Linked Life Data

2535141

Source:http://linkedlifedata.com/resource/pubmed/id/2535141

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-5-29
pubmed:abstractText
Information was sought on the antigen-presenting cells (APC) required for stimulating primary mixed-lymphocyte reactions (MLR) by unprimed Lyt-2+ cells in the absence of added lymphokines. Like L3T4+ cells, Lyt-2+ cells gave very high MLR in response to H-2-different dendritic cells (DC). Surprisingly, high MLR were also elicited by thioglycollate-induced peritoneal exudate cells (PEC), including Ia- PEC; these cells were non-immunogenic for L3T4+ cells. Since PEC consisted almost entirely of macrophages (M phi), the data suggest that at least two different cell types, DC and M phi, can express APC function for unprimed Lyt-2+ cells. Since resident peritoneal M phi and in vitro cultured PEC were poorly immunogenic, the APC function of M phi might be limited to a subset of these cells, e.g. to immature M phi.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0953-8178
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
517-25
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Antigen-presenting cells for Lyt-2+ cells. II. Primary mixed-lymphocyte reactions stimulated by Ia+ dendritic cells and Ia- peritoneal exudate cells.
pubmed:affiliation
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.