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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-5-31
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pubmed:abstractText |
Sodium arachidonate (NaAr) at a dose of 1.1 mg/kg injected i.v. is uniformly lethal in rabbits within 5 min. This sudden death is typified by a precipitous drop in mean arterial blood pressure, a dramatic decrease in the circulating platelet count, and by a marked rise in plasma thromboxane A2 (TxA2) concentration as measured by radioimmunoassay of its breakdown product, TxB2. Pretreatment with S-145, a new thromboxane receptor antagonist, at doses ranging from 50 to 500 micrograms/kg resulted in 100% survival of all the rabbits subjected to sodium arachidonate injection. However, at 20 micrograms/kg S-145 only 25% of the rabbits challenged with NaAr survived. S-145 pretreatment also inhibited the decreases in circulating platelet count and in blood pressure associated with the i.v. injection of sodium arachidonate (NaAr). S-145 blunted the rise in plasma TxB2 concentration at all doses. S-145 was also shown to be a potent and long-lasting antagonist of TxA2 receptors in isolated rabbit aortic rings. Our data show that S-145 is a very effective protective agent against NaAr-induced sudden death in rabbits.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9...,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Bridged Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Monounsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin Endoperoxides...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thromboxane,
http://linkedlifedata.com/resource/pubmed/chemical/S 145,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane B2
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pubmed:status |
MEDLINE
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pubmed:issn |
0934-9820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2534470-15-Hydroxy-11 alpha,9...,
pubmed-meshheading:2534470-Animals,
pubmed-meshheading:2534470-Aorta, Thoracic,
pubmed-meshheading:2534470-Arachidonic Acid,
pubmed-meshheading:2534470-Arachidonic Acids,
pubmed-meshheading:2534470-Bicyclo Compounds,
pubmed-meshheading:2534470-Blood Pressure,
pubmed-meshheading:2534470-Bridged Compounds,
pubmed-meshheading:2534470-Death, Sudden,
pubmed-meshheading:2534470-Disease Models, Animal,
pubmed-meshheading:2534470-Fatty Acids, Monounsaturated,
pubmed-meshheading:2534470-Male,
pubmed-meshheading:2534470-Platelet Count,
pubmed-meshheading:2534470-Prostaglandin Endoperoxides, Synthetic,
pubmed-meshheading:2534470-Rabbits,
pubmed-meshheading:2534470-Radioimmunoassay,
pubmed-meshheading:2534470-Receptors, Prostaglandin,
pubmed-meshheading:2534470-Receptors, Thromboxane,
pubmed-meshheading:2534470-Thromboxane B2
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pubmed:year |
1989
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pubmed:articleTitle |
Protective actions of a new potent thromboxane receptor antagonist in arachidonate induced sudden death.
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pubmed:affiliation |
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
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pubmed:publicationType |
Journal Article,
In Vitro
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