|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1990-3-7
|
|
pubmed:abstractText |
1. Ten different NSAIDs were used in a comparative study of their effects upon rat liver mitochondrial and human platelet functions. 2. The drugs behaved like uncouplers of mitochondrial respiration, decreased membrane potential, stimulated ATPase activity and had an ionophore-like effect upon calcium transport. 3. In vitro experiments showed the same effect with 45Ca as well as 22Na. 4. In platelets, aggregation was considerably reduced by most NSAIDs. 5. Addition of ADP (mitochondrial calcium uptake) or magnesium (platelet aggregation and in vitro cation transference) contributed to protect from those effects.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0020-711X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1387-94
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2533113-Adenosine Triphosphatases,
pubmed-meshheading:2533113-Animals,
pubmed-meshheading:2533113-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:2533113-Biological Transport,
pubmed-meshheading:2533113-Calcium,
pubmed-meshheading:2533113-Humans,
pubmed-meshheading:2533113-Ionophores,
pubmed-meshheading:2533113-Membrane Potentials,
pubmed-meshheading:2533113-Mitochondria, Liver,
pubmed-meshheading:2533113-Mitochondrial Swelling,
pubmed-meshheading:2533113-Oxidative Phosphorylation,
pubmed-meshheading:2533113-Oxygen Consumption,
pubmed-meshheading:2533113-Platelet Aggregation,
pubmed-meshheading:2533113-Platelet Aggregation Inhibitors,
pubmed-meshheading:2533113-Rats
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
A comparative study of the effect of ten non-steroidal anti-inflammatory drugs (NSAIDs) upon some mitochondrial and platelet functions.
|
|
pubmed:affiliation |
Departamento de Bioquimica, Instituto Nacional de Cardiologia Ignacio Chavez, México, D.F. México.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
|
