Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1990-2-20
|
| pubmed:abstractText |
1. The effects of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) on urinary protein excretion were examined in nine healthy subjects and 20 patients with primary glomerular diseases who had proteinuria of 1.0 g or more per day. Synthetic alpha-hANP was intravenously infused into supine subjects at a rate of 8.3 pmol min-1 kg-1 for 40 min. 2. Before alpha-hANP infusion, the plasma concentration of immunoreactive alpha-hANP was significantly higher in the patients with glomerulonephritis than in the normal subjects (44.3 +/- 8.7 vs 19.4 +/- 3.0 pmol/l, mean +/- SEM, P less than 0.01) and it showed a positive correlation with mean arterial pressure (rs = 0.84, P less than 0.001) and a negative correlation with creatinine clearance (rs = -0.50, P less than 0.01). 3. During infusion of alpha-hANP, although the urinary excretion of protein did not change significantly in the normal subjects, it increased from 0.6 +/- 0.2 to 3.0 +/- 0.8 mg min-1 m-2 (P less than 0.001) in the patients with glomerulonephritis. The urinary protein/creatinine ratio did not change significantly in the former (from 0.18 +/- 0.05 to 0.22 +/- 0.06; NS), whereas it rose from 3.25 +/- 0.94 to 7.62 +/- 1.31 (P less than 0.001) in the latter. 4. The urinary excretions of albumin and of alpha 1-, alpha 2-, beta- and gamma-globulins, which were electrophoretically analysed, all increased in eight nephrotic patients during or immediately after infusion of alpha-hANP.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/p-Aminohippuric Acid
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0143-5221
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
77
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
643-50
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2532580-Adolescent,
pubmed-meshheading:2532580-Adult,
pubmed-meshheading:2532580-Aged,
pubmed-meshheading:2532580-Albuminuria,
pubmed-meshheading:2532580-Atrial Natriuretic Factor,
pubmed-meshheading:2532580-Creatinine,
pubmed-meshheading:2532580-Female,
pubmed-meshheading:2532580-Glomerular Filtration Rate,
pubmed-meshheading:2532580-Glomerulonephritis,
pubmed-meshheading:2532580-Hematocrit,
pubmed-meshheading:2532580-Humans,
pubmed-meshheading:2532580-Kidney,
pubmed-meshheading:2532580-Male,
pubmed-meshheading:2532580-Middle Aged,
pubmed-meshheading:2532580-Proteinuria,
pubmed-meshheading:2532580-Renin,
pubmed-meshheading:2532580-Sodium,
pubmed-meshheading:2532580-Time Factors,
pubmed-meshheading:2532580-p-Aminohippuric Acid
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Effect of alpha-human atrial natriuretic peptide on proteinuria in patients with primary glomerular diseases.
|
| pubmed:affiliation |
Second Department of Internal Medicine, University of Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|