Linked Life Data

2532554

Source:http://linkedlifedata.com/resource/pubmed/id/2532554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-2-13
pubmed:abstractText
We have studied the effects of low-dose recombinant interleukin-2 preceded by low-dose cyclophosphamide on malignant melanoma. Thirty eight outpatients aged from 25 to 75 years were treated with interleukin-2, 3.6 million Cetus units/m2 i.v. daily for five days on two successive weeks beginning three days after 350 mg/m2 of intravenous cyclophosphamide. This schedule was repeated at least twice more with a one-week interval between cycles, usually at the same dosage level. Ten of the 38 patients (26.3%) had clinically significant remissions: two complete (5.3%), seven partial (18.4%), and one ongoing, long-term (greater than 18 mo) "minor" response (2.6%). Four others (10.5%) had shorter minor responses and four (10.5%) a mixed response. One patient with disease restricted to the skin had a complete remission, while the other patient with a complete remission had had three lung nodules and an enlarged hilar lymph node. It was gratifying that one of the major sites of disease responding to treatment was the liver. Two complete and two partial remissions (i.e., greater than 50% regressions for greater than four weeks at this site) were obtained in 10 patients with liver involvement. Lung metastases also responded in four of 16 patients (one complete and three partial remissions). Subcutaneous nodules responded in seven of 21 patients (two complete, five partial remissions), while lymph node metastases diminished significantly in four of 14 patients (one complete, three partial remissions). The median duration of response was nine months (range, 1.5-20 months), with four patients treated for more than one year. Toxicity was moderate and controllable, and only two patients required hospitalization, both overnight. Lymphokine activated killer cell activation was induced in 24 of 38 patients, including all nine of the major responders. Conversely, none of 14 patients without lymphokine activated killer cell activation had a significant clinical remission. This regimen appeared to be as effective in melanoma as those involving ex vivo activation of lymphokine activated killer cells, and was more tolerable than therapy with high doses of interleukin-2.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-131175, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-3123025, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-3262416, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-3491225, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-3493432, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-3493433, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-3903508, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-6176669, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-6229330, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-6382555, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-6488195, http://linkedlifedata.com/resource/pubmed/commentcorrection/2532554-7334070
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-7091
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
128-44
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Low-dose cyclophosphamide and low-dose interleukin-2 for malignant melanoma.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't