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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
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pubmed:dateCreated |
1990-1-30
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|
pubmed:abstractText |
Herein we have investigated the ability of antigen to induce thymocyte death by apoptosis on the basis that this may be the mechanism for the deletion of autoreactive cells during T cell development. We show that the ability of the bacterial "superantigen" staphylococcal enterotoxin B to cause specific depletion of V beta 8+ cells when added to thymus organ cultures is accompanied by DNA degradation into oligonucleosomal fragments, indicating that depletion involves apoptosis. Our results provide the first direct evidence that antigen-induced apoptosis can be triggered in developing T cells.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0014-2980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2175-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2532142-Animals,
pubmed-meshheading:2532142-Cell Survival,
pubmed-meshheading:2532142-DNA Damage,
pubmed-meshheading:2532142-Enterotoxins,
pubmed-meshheading:2532142-Mice,
pubmed-meshheading:2532142-Organ Culture Techniques,
pubmed-meshheading:2532142-Receptors, Antigen, T-Cell,
pubmed-meshheading:2532142-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:2532142-T-Lymphocytes,
pubmed-meshheading:2532142-Thymus Gland
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|
pubmed:year |
1989
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|
pubmed:articleTitle |
Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire.
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pubmed:affiliation |
Department of Anatomy, Medical School, University of Birmingham.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
