Linked Life Data

2531112

Source:http://linkedlifedata.com/resource/pubmed/id/2531112

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-1-9
pubmed:abstractText
The alloantigen responses of hemophilic patients was evaluated using a unidirectional mixed lymphocyte culture (MLC). The results of this study indicate that both the ability of peripheral blood mononuclear cells (PBMC) to proliferate in response to alloantigens and the capacity to stimulate the MLC are impaired in hemophilic patients infected with the human immune deficiency virus (HIV). These defects cannot be overcome by addition of exogenous interleukin-2 (IL-2) and are not related to the absence of IL-2 receptors (IL-2R). Lack of response was evident in PBMC from HIV+ patients with a high proportion of IL-2R+ cells. The number of IL-2 cells was similar in HIV+ and HIV- individuals, and higher than that of normal controls. Impaired MLC proliferation was not related to the occurrence of clinical symptoms. Apparently, MLC is a useful procedure for distinguishing the cell mediated immunity defects associated with HIV infection and unrelated to replacement therapy in hemophilia patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0390-6078
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Impaired response to alloantigens in HIV positive hemophilic patients.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't