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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1989-12-21
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pubmed:databankReference |
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pubmed:abstractText |
cDNA clones of the interleukin 1 (IL-1) receptor expressed in a human T-cell clone have been isolated by using a murine IL-1 receptor cDNA as a probe. The human and mouse receptors show a high degree of sequence conservation. Both are integral membrane proteins possessing a single membrane-spanning segment. Similar to the mouse receptor, the human IL-1 receptor contains a large cytoplasmic region and an extracellular, IL-1 binding portion composed of three immunoglobulin-like domains. When transfected into COS cells, the human IL-1 receptor cDNA clone leads to expression of two different affinity classes of receptors, with Ka values indistinguishable from those determined for IL-1 receptors in the original T-cell clone. An IL-1 receptor expressed in human dermal fibroblasts has also been cloned and sequenced and found to be identical to the IL-1 receptor expressed in T cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2447127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2470087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2524527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2783320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2783498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2783592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2898301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2937055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2940296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2944981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2946958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2946959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2947968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2952728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2956124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2960676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2961613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2963818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2967293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2969618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-2969895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3011895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3029093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3073548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3104451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3160805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3257968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3261603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3262785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3264252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3291115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3486814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-3548772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-6264478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-6460819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530587-822353
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8946-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2530587-Amino Acid Sequence,
pubmed-meshheading:2530587-Animals,
pubmed-meshheading:2530587-B-Lymphocytes,
pubmed-meshheading:2530587-Base Sequence,
pubmed-meshheading:2530587-Cloning, Molecular,
pubmed-meshheading:2530587-DNA,
pubmed-meshheading:2530587-Fibroblasts,
pubmed-meshheading:2530587-Gene Expression,
pubmed-meshheading:2530587-Genes,
pubmed-meshheading:2530587-Humans,
pubmed-meshheading:2530587-Interleukin-1,
pubmed-meshheading:2530587-Kinetics,
pubmed-meshheading:2530587-Mice,
pubmed-meshheading:2530587-Molecular Sequence Data,
pubmed-meshheading:2530587-Receptors, Antigen, T-Cell,
pubmed-meshheading:2530587-Receptors, Immunologic,
pubmed-meshheading:2530587-Receptors, Interleukin-1,
pubmed-meshheading:2530587-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2530587-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
Cloning the interleukin 1 receptor from human T cells.
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pubmed:affiliation |
Immunex Corp., Seattle, WA 98101.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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