Linked Life Data

2530474

Source:http://linkedlifedata.com/resource/pubmed/id/2530474

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-12-1
pubmed:abstractText
The recent finding that D1 dopamine receptors are present in all neocortical areas of the human brain, does not fit in with the generally held view that the mesocortical dopaminergic pathway is restricted to prefrontal areas. We investigated the brains of 3 patients who died with a unilateral infarction in the ventral midbrain, including the substantia nigra and ventral tegmental area. Compared to the intact side, the D1 receptors in frontal, temporal, parietal and occipital cortices and caudate nucleus at the lesioned side were increased by 27-37%, which is consistent with an up-regulation in response to a depletion of dopamine. These data provide evidence for a more widespread dopaminergic innervation of the human neocortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Evidence for a widespread dopaminergic innervation of the human cerebral neocortex.
pubmed:affiliation
Department of Neurology, Academisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't