Linked Life Data

2530315

Source:http://linkedlifedata.com/resource/pubmed/id/2530315

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1989-12-1
pubmed:abstractText
Previous studies have shown that the mammalian neostriatum contains two subtypes of D2 dopamine receptors, which can be distinguished on the basis of the ability of GTP to convert high (RH) into low (RL) affinity sites for dopamine: GTP-sensitive (GS) and GTP-insensitive (GI) D2 receptors. The GI-D2 receptors in rat and human neostriatum are confined to the corticostriatal terminals. In rats, these receptors mediate the inhibitory effect of dopamine on the release of glutamate in the striatum. Here we report that the putamen in Huntington's disease (HD) lacks GI-D2 receptors. Their absence might be responsible for an inappropriate release of glutamate, which is neurotoxic in high concentrations, and might thus contribute to striatal cell death in HD.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Lack of GTP-insensitive D2 dopamine receptors in Huntington's disease.
pubmed:affiliation
Department of Neurology, Vrije Universiteit Brussel, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't