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rdf:type |
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lifeskim:mentions |
umls-concept:C0001779,
umls-concept:C0019163,
umls-concept:C0020971,
umls-concept:C0042210,
umls-concept:C0150647,
umls-concept:C0205473,
umls-concept:C0871261,
umls-concept:C1522384,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
1989-11-24
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pubmed:abstractText |
The efficacy and acceptability of yeast-derived recombinant hepatitis B vaccine given by the intradermal route was investigated in 221 health care volunteers. Two hundred and sixteen received a full course of three doses of vaccine. Only one subject was withdrawn because of a significant adverse reaction (psoriasis). The vaccine stimulated an antibody response in 81%. The response to the vaccine was better in women than in men (87% compared with 71%, p = 0.007) and in women below the age of 40 years compared with older women (94% compared with 76%, p = 0.01). For men the response showed a sequential decline with age for each decade (90% responders from age 29 or less, 72% aged 30-39 and 65% aged 40 or more, p = 0.04). Retrospective enquiry showed that over 90% had found the intradermal route acceptable and 59% would prefer vaccine by the intradermal route in preference to intramuscular notwithstanding local reactions. Although the seroconversion rate was of a high order in younger women the antibody titres were not high with only 9 of 215 recipients developing titres greater than 1000 mIU/ml, a level which could be expected to ensure prolonged immunity. A fourth intradermal dose of vaccine given to 60 volunteers who had shown a low response (less than 38 mIU/ml) or no serological response to a three-dose course stimulated a good booster effect (to 150-600 mIU/ml) in only 5 (8%).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2439007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2878212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2880225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2887843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2892077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2941599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2944039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2944466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2946277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2950303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2950344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2956121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-2963570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-3317357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-3541426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-3859534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-4075592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-6140546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2530104-6150233
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0950-2688
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
387-94
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:2530104-Adult,
pubmed-meshheading:2530104-Age Factors,
pubmed-meshheading:2530104-Female,
pubmed-meshheading:2530104-Hepatitis B Antibodies,
pubmed-meshheading:2530104-Hepatitis B Vaccines,
pubmed-meshheading:2530104-Hepatitis B virus,
pubmed-meshheading:2530104-Humans,
pubmed-meshheading:2530104-Injections, Intradermal,
pubmed-meshheading:2530104-Male,
pubmed-meshheading:2530104-Middle Aged,
pubmed-meshheading:2530104-Retrospective Studies,
pubmed-meshheading:2530104-Sex Factors,
pubmed-meshheading:2530104-Vaccines, Synthetic,
pubmed-meshheading:2530104-Viral Hepatitis Vaccines
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pubmed:year |
1989
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pubmed:articleTitle |
Intradermal hepatitis B immunization with yeast-derived vaccine: serological response by sex and age.
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pubmed:affiliation |
Public Health Laboratory, Royal Shrewsbury Hospital, Shropshire.
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pubmed:publicationType |
Journal Article
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