Linked Life Data

2529904

Source:http://linkedlifedata.com/resource/pubmed/id/2529904

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-12-13
pubmed:abstractText
Evidence for metabolic esterification of dehydroepiandrosterone (DHEA) in human blood plasma, identification of the active lipoprotein (LP) subclass involved, namely HDL3, as well as positive identification of the long-chain fatty acid esters of DHEA formed as incubation products is presented. The esterification reaction of DHEA and subsequent transfer and transport of DHEA esters in human plasma appears to proceed in a manner similar to that of cholesterol. The experiments presented serve as a model predicting similar metabolic transformations during HDL3 interactions with other steroid hormones that have the delta 5-3 beta-hydroxy steroid ring structure and exhibit nonequilibrium associations with HDL. These observations imply that significant quantities of DHEA, particularly in the conjugated ester form, can enter cells via the membrane receptor-mediated pathways of LP internalization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
1014
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Esterification of dehydroepiandrosterone by human plasma HDL.
pubmed:affiliation
Harlan E. Moore Heart Research Foundation, Champaign, IL 61820.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't