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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-11-2
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pubmed:abstractText |
Studies were conducted to examine the effects of chronic adrenalectomy (Adx) and adrenalectomy plus glucocorticoid replacement therapy on rat cardiac contractile protein ATPase activities. The Ca2+-dependent Mg-ATPase activity of myofibrils isolated from rat ventricles 3 weeks postadrenalectomy (Adx) was significantly decreased at all pCa2+ concentrations (P less than 0.01), compared to sham-operated (SO) rats. Similarly, Ca2+-, K+-EDTA, and actin-activated myosin ATPase activities of Adx rat hearts were markedly decreased below that of SO rats (P less than 0.01). Dexamethasone administration to Adx rats prevented the decrease of Ca2+- and K+-ATPase activities of myosin, but not of myofibrillar Ca2+-dependent Mg-ATPase or actin-activated myosin Mg-ATPase activities. These studies suggest that glucocorticoid insufficiency induced by adrenalectomy results in altered myocardial contractile protein ATPase activity which may underlie impaired cardiac performance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0885-4505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
118-24
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2528974-Adenosine Triphosphatases,
pubmed-meshheading:2528974-Adrenalectomy,
pubmed-meshheading:2528974-Animals,
pubmed-meshheading:2528974-Ca(2+) Mg(2+)-ATPase,
pubmed-meshheading:2528974-Calcium-Transporting ATPases,
pubmed-meshheading:2528974-Corticosterone,
pubmed-meshheading:2528974-Dexamethasone,
pubmed-meshheading:2528974-Glucocorticoids,
pubmed-meshheading:2528974-Male,
pubmed-meshheading:2528974-Myocardium,
pubmed-meshheading:2528974-Myofibrils,
pubmed-meshheading:2528974-Myosins,
pubmed-meshheading:2528974-Rats,
pubmed-meshheading:2528974-Rats, Inbred Strains
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pubmed:year |
1989
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pubmed:articleTitle |
Changes in myocardial contractile protein ATPases in chronically adrenalectomized rats with and without glucocorticoid replacement.
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pubmed:affiliation |
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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