Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-10-26
|
| pubmed:abstractText |
The CD4+ lymphocyte depletion in human immunodeficiency virus (HIV)-infected persons seems to be affected by HIV products. As the dynamics of the concentration of HIV products is reciprocal to that of non-replicating antigen used for induction of tolerance, the mathematical model of immunological tolerance can be used to describe the dynamics of CD4+ lymphocyte depletion. To stimulate the clinically observed dynamics, it is necessary to include the limitation of HIV growth by the corresponding cytotoxic T cells and their dependence on the helper effect of CD4+ lymphocytes. Simulation analysis suggests that qualitatively similar results are obtained if immature, mature, or both categories of CD4+ lymphocytes considered in the model are depleted by the HIV products.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0015-5500
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
156-63
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2528479-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2528479-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2528479-Humans,
pubmed-meshheading:2528479-Immune Tolerance,
pubmed-meshheading:2528479-Mathematics,
pubmed-meshheading:2528479-Models, Biological,
pubmed-meshheading:2528479-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:2528479-Time Factors
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Mathematical model of CD4+ lymphocyte depletion in HIV infection.
|
| pubmed:affiliation |
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
|
| pubmed:publicationType |
Journal Article
|