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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-10-3
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pubmed:abstractText |
U937 monocytic cells were found to respond by diminished spontaneous migration when confronted with affinity-purified soluble fragments of the low-affinity receptor for IgE (FcER2/CD23). Unlike B lymphoma cells, U937 cells could not be activated to respond with enhanced DNA synthesis through their membrane-bound CD23 antigen by MHM6, a monoclonal antibody within the CD23 cluster. MHM6 did, however, effectively neutralize the U937-directed MIF (migration inhibition factor) activity contained within the soluble CD23 preparations. The findings not only suggest a role for soluble CD23 as a novel cytokine at sites of inflammation but also indicate different functions for the membrane-bound forms expressed on B cells and monocytes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-178611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-2438206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-2522048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-2525911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-2847932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-2877743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-2957693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-2969400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-2972386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-3033649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-3038527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-3260186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527805-6160404
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Leukocyte Migration-Inhibitory...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
547-9
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:2527805-Antibodies, Monoclonal,
pubmed-meshheading:2527805-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:2527805-Cell Migration Inhibition,
pubmed-meshheading:2527805-Humans,
pubmed-meshheading:2527805-Immunoglobulin E,
pubmed-meshheading:2527805-Leukocyte Migration-Inhibitory Factors,
pubmed-meshheading:2527805-Lymphokines,
pubmed-meshheading:2527805-Monocytes,
pubmed-meshheading:2527805-Peptide Fragments,
pubmed-meshheading:2527805-Receptors, Fc,
pubmed-meshheading:2527805-Receptors, IgE,
pubmed-meshheading:2527805-Solubility
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pubmed:year |
1989
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pubmed:articleTitle |
Soluble fragments of the low-affinity IgE receptor (CD23) inhibit the spontaneous migration of U937 monocytic cells: neutralization of MIF-activity by a CD23 antibody.
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pubmed:affiliation |
Department of Immunology, University of Birmingham, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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